88869 comments

• Comment Link Viernes, 30 Enero 2026 20:30 posted by Fluconazole

  Activity is pH-dependent, with optimal efficacy in neutral to slightly acidic environments.
• Comment Link Viernes, 30 Enero 2026 20:30 posted by Fluconazole

  QTc interval prolongation is a rare but serious potential adverse effect.
• Comment Link Viernes, 30 Enero 2026 20:30 posted by Diflucan

  Diflucan is intrinsically ineffective against Mucorales, necessitating alternative therapy.
• Comment Link Viernes, 30 Enero 2026 20:30 posted by Fluconazole

  Diflucan is not recommended for treatment of Pneumocystis jirovecii pneumonia.
• Comment Link Viernes, 30 Enero 2026 20:29 posted by Fluconazole

  Protein binding is relatively low (~12), contributing to good tissue distribution.
• Comment Link Viernes, 30 Enero 2026 20:29 posted by Diflucan (Fluconazole)

  Diflucan can cause taste distortion (dysgeusia) as a side effect.
• Comment Link Viernes, 30 Enero 2026 20:27 posted by Fluconazole (Diflucan)

  Loading doses are used in serious infections to achieve steady-state concentrations rapidly.
• Comment Link Viernes, 30 Enero 2026 20:27 posted by Diflucan (Fluconazole)

  Diflucan is not a substrate of the P-glycoprotein efflux pump, aiding its distribution.
• Comment Link Viernes, 30 Enero 2026 20:26 posted by Diflucan

  Serves as a model for the development of other triazole antifungal agents.
• Comment Link Viernes, 30 Enero 2026 20:25 posted by Diflucan

  Diflucan lacks activity against Histoplasma in the CNS, unlike itraconazole.