
// DOCENTE OCASIONAL //
Maestría en Ingeniería de Sistemas y Computación
pregrado
Ingeniero Electrónico

// DOCENTE OCASIONAL //
Maestría en Ingeniería de Sistemas y Computación
pregrado
Ingeniero Electrónico
Diflucan is not active against the dimorphic fungus Blastomyces dermatitidis.
Diflucan's mechanism is inhibition of fungal cytochrome P450, disrupting ergosterol synthesis.
Diflucan can increase sulfonylurea levels, increasing hypoglycemia risk.
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Its high selectivity for fungal enzymes over human ones is key to its relatively low toxicity.
The long half-life (~30 hours) enables convenient once-daily dosing regimens.
Activity against Coccidioides immitis makes it useful for certain non-meningeal forms of valley fever.
Teratogenicity concerns (Category D) limit its use in pregnancy, especially first trimester.
Its cost-effectiveness is a significant advantage over newer, broader-spectrum azoles.
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